The sermon focuses on Matthew 16:21-28, where Jesus predicts His suffering, death, and resurrection. The sermon explores how Peter initially confesses Jesus as the Messiah but soon becomes a "stumbling block" by opposing God's plan for Jesus to suffer. Jesus rebukes Peter, emphasizing that following Him requires self-denial and bearing one's cross. The sermon outlines three key lessons: Jesus will suffer, die, and rise; His disciples must follow Him in suffering and self-denial; and, ultimately, they will be rewarded. The sermon encourages listeners to embrace this path of discipleship, trusting in the eternal reward that comes from following Jesus.